Overexpression of the MACC1 and correlation of its expression with HPV infection in cervical cancer

Hongxia Chai*, Xinghu Zhou**, Jing Wang1, Yan Ge*, Yongxiu Yang*

*Department of Obstetrics and Gynecology, the First Affiliated Hospital of Lanzhou University, Lanzhou 730000, China - **Department of Cardiology, the First Affiliated Hospital of Lanzhou University, Lanzhou 730000, China

Introduction: In China, the incidence of cervical cancer is the highest among women. MACC1 was recently identified a key gene controlling tumor growth and metastasis. The purpose of this study is to evaluate significance of the MACC1 expression in cervical neoplastic lesions tissues and investigate the relationships between MACC1 expression and human papillomavirus (HPV) infection.

Case presentations: Immunohistochemistry was performed to determine MACC1expression in 100 cervical cancer tissues, 20 cervical intraepithelial neoplasia (CIN) and 40 normal cervical tissues. HPV DNA was detected by polymerase chain reaction (PCR) in the same cases. The association of MACC1 expression with HPV infection was assessed. MACC1 and HPV DNA expression levels were increased in cervical carcinoma and CIN tissues compared to normal cervical tissues (P< 0.0005). High cytoplasmic expression of MACC1 was significantly associated with clinicopathological variables (P< 0.05). MACC1 expression was significantly correlated with HPV DNA level (Spearman r=0.420, P< 0.05).

Conclusions: MACC1 may play an important role in tumor progression and be a potential marker of diagnosis and genetic therapy for cervical cancer. Overexpression of MACC1 complex strongly correlates with oncogenic HPV infection, which may stimulate cell proliferation and participate in tumor progression in oncogenic HPV-infected lesions.