INCREASED SERUM SCD40L AND GGT, AS WELL AS DECREASED SFRP5, ARE CORRELATED WITH CORONARY ARTERY STENOSIS

Wenjie Hu*, Honglei Cao**, #, Wei Zhou***

*Department of Cardiovascular, Lu'an People's Hospital, Lu’an, PR China - **Department of Cardiology, Jining NO.1 People's Hospital, Jining, PR China - ***Department of Cardiology, The 72nd Group Military Hospital of Chinese PLA, Jinan, PR China

Objective: To investigate the correlation between serum sCD40L, GGT, and SFRP5 levels and coronary atherosclerosis in patients with coronary heart disease. 

Methods: 102 patients with CHD who were treated in our hospital from December 2017 to September 2018 were randomly selected to form the observation group. According to the lesion range, 40 patients in the single-vessel disease group, 45 patients in the double-vessel disease group, 17 cases in the multi-vessel disease group, and 50 healthy volunteers who were in the hospital for physical examination at the same time were selected to form the control group. The patients with CHD were given fasting venous blood on the day after hospitalisation. The levels of soluble leukocyte differentiation antigen 40 ligand (sCD40L) and placental growth factor (PIGF) were detected by an enzyme-linked immunosorbent assay (ELISA). The level of γ-glutamyltransferase (GGT) was detected by an enzyme rate method. The ELISA was used for the detection of secreted frizzled protein-related protein-5 (SFRP5) levels. The degree of vascular disease was scored using Gensini scores. Alanine aminotransferase (ALT) and total bilirubin (TBIL) were detected using an automatic biochemical analyser. The sCD40L, PIGF, GGT, SFRP5, ALT, TBIL levels, and Gensini scores were compared between the two groups. The correlation between sCD40L, GGT, and SFRP5 levels and coronary atherosclerosis was analysed. 

Results: The serum levels of sCD40L and PIGF in the subgroups of the observation group were significantly higher than those in the control group (P<0.05). The scores of sCD40L, PIGF, and Gensini in the multi-vessel disease group were significantly higher than those in the double-vessel disease group and the single-vessel disease group (P<0.05). The levels of ALT and GGT in the subgroups of the observation group were significantly higher than those in the control group, and the TBIL levels were significantly lower than those in the control group (P<0.05). The ALT and GGT levels in the multi-vessel disease group were significantly higher than those in the double-vessel disease group and the single-vessel disease group. The TBIL level for this group was significantly lower than that in the double-vessel disease group and the single-vessel disease group (P<0.05). The level of SFRP5 in the subgroups of the observation group was significantly lower than that of the control group (P<0.05). The level of SFRP5 in the multi-vessel disease group was significantly lower than that in the double-vessel disease group and the single-vessel disease group (P<0.05). Serum sCD40L and GGT were positively correlated with the degree of coronary artery stenosis, and SFRP5 was negatively correlated with the degree of coronary artery stenosis. 

Conclusion: Serum sCD40L and GGT levels are elevated in patients with coronary heart disease while SFRP5 levels are decreased. Therefore, serum sCD40L and GGT are positively correlated with coronary artery stenosis and SFRP5 is negatively correlated with coronary artery stenosis.