HEMODYNAMICS OF CAROTID ARTERY BIFURCATION BETWEEN HEALTHY AND STENOSED MODEL BASED ON HUMAN MODEL

Mingcheng Hu*, Jinxing Guo**, Yanbin Sun***, Tingting Fan****, ****, Dongliang Zhao******, Guangxin Chen*******,#

*Department of Radiology, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, China - **The first outpatient department of Hongqi Hospital Affiliated to Mudanjiang Medical University,Mudanjiang, China - ***Medicine college of  Mudanjiang Medical University, Mudanjiang, China - ****State Key Laboratory for Turbulence and Complex Systems, College of Engineering, Peking University, Beijing, China - *****School of  Biomedical Engineering, Capital Medical University Beijing, China - ******Department of Mechanics and Engineering Science, Peking University, Beijing, China - *******Medical Image College of Mudanjiang Medical University, Mudanjiang, China

Objective: The carotid artery plays an important role in transporting the blood to the brain, and the atherosclerosis is a common disease to develop the stenosed carotid artery. Local hemodynamics are an important factor in atherosclerosis, from the development of early lesions, to the assessment of stroke risk, to determining the ultimate fate of a mature plaque.

Methods: To evaluate the stenosed carotid artery, the computational fluid dynamics (CFD) method can been used to get TAWSS, OSI, and TAWSSG. We hypothesize that hemodynamic patterns are determined by the interplay of carotid artery geometry, anastomotic configuration, and severity of native coronary artery stenosis, which are strongly affected by the postoperative time. A 3D finite volume method with the inlet velocity wave and outlet resistance boundary conditions was used to compute the distribution of pressure and flow. The healthy and the stenosed patient carotid arteries have been used for our simulation. 

Results: The major findings are reported as: 1) smaller diameter and big stenosis rate in the stenosed model. 2) the stenosed carotid arteries has the lower WSS and higher OSI compared the healthy carotid arteries. 

Conclusion: Local hemodynamics are an important factor in atherosclerosis, from the development of early lesions, to the assessment of stroke risk, to determining the ultimate fate of a mature plaque.