1Anorectal Department, Tangshan Gongren Hospital,Tangshan,063000,Hebei,China - 2Outpatient Operating Room, Tangshan Gongren Hospital, Tangshan 063000, Hebei, China


Purpose: The specific conditions of patients with acute craniocerebral injury, the extent, location, nature of the injury, and the association of the occurrence of mental disorders were analyzed. The specific changes of IL-1β, IL-6, TNF-a and cortisol in the serum of patients with early mental symptoms caused by acute craniocerebral injury were monitored.

Method: 275 patients with acute craniocerebral injury were selected from Tangshan Gongren Hospital. The patient's relevant information was sorted out. The effects of multiple factors on early mental symptoms in patients with acute craniocerebral injury were analyzed. Peripheral venous blood samples were collected on the first day, the third day, the seventh day, the 15th day, the 21st day, and the 30th day of the hospitalization. Serum levels of IL-1β, IL-6, TNF-a and cortisol were measured by enzyme-linked immunosorbent assay (ELISA) and their specific trends were compared.

Result: The degree of education, age and specific nature, location and extent of traumatic brain injury were correlated with the occurrence of early psychiatric symptoms (P<0.01). Compared with patients in the non-mental disorder group, there was no change in the serum IL-1β, IL-6, and TNF-a levels on the first day after the injury in the mental disorder group. However, on the 3rd, 7th, 15th, 21st, and 30th days after the injury, the relevant index of the mental disorder group was higher than that of the non-mental disorder group (P<0.05). The indicators of the mental disorder group reached a peak on the 7th day after the injury and then gradually decreased.

Conclusion: During clinical treatment of patients with craniocerebral injury, high-risk patients should be evaluated in a targeted manner. At the same time, the patient's mental symptoms should be observed and some targeted interventions and treatments should be carried out. The serum levels of IL-1β, IL-6, TNF-a and cortisol were monitored dynamically. This provides guidance for clinical eva- luation of the occurrence, development and observation of early mental symptoms of acute craniocerebral injury and has very high clini- cal value.


acute craniocerebral injury, early mental disorder, cytokines, cortisol.


DOI: 10.19193/0393-6384_2019_1s_72