Xuefeng Ma1, Xu He1, Xiaoqi Zhu2, Anmin Jin3


1Department of Spine, Shenzhen Ping Le Orthopedics Hospital, Shenzhen 518000, China - 2Department of orthopedics, Bao’an People’s Hospital, Shenzhen 518000, China - 3Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China


 Objective: To study the effects of limb fracture combined with cranial nerve injury on bone mineral density, bone microstructure and bone metabolism.

Method: 42 patients were randomly divided into simple fracture group and brain injury and fracture group. Serum samples, bone mineral density and levels of serum amino-terminal peptides and osteocalcin were analyzed at 3rd week, 6th week and 3rd month after operation.

Results: compared with the fracture group, the volume fraction of the cancellous bone, the thickness of the trabecular bone, the total area of the tibial cortical cross section, serum collagen N telopeptide and osteocalcin level of the brain injury and fracture group were significantly higher in the 3rd and 6th week after operation, and there was no significant difference between the two groups 3 months after the operation.

Conclusion: cranial nerve injury can increase local bone mineral density and improve bone microstructure so that to promote bone healing and bone metabolism.


Fracture, Cranial Nerve Injury, Fracture Healing