CHANGES OF OXIDATIVE STRESS AND SERUM ISCHEMIC MODIFIED PROTEIN LEVELS IN PATIENTS WITH CARDIAC ARREST AFTER CARDIOPULMONARY RESUSCITATION

Jinming Xia, Xia Wei, Dengpan Lai, ShiJin Lv

Department of Emergency, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang, China

Objective: Clarify the change rule of oxidative stress index and ischemic modification protein content in patients with cardiac arrest after cardiopulmonary resuscitation and determine the effective prognostic indicators of patients with cardiac arrest after car- diopulmonary resuscitation.

Methods: By collecting blood from patients with cardiac arrest treated with CPR and normal people, the oxidative stress indi- cators in the blood pool of the two groups are measured, including the activity levels of malondialdehyde, superoxide dismutase and glutathione peroxidase, and the changes of serum oxidative stress index between the groups are analyzed. The normal population is used as a control to detect changes in IMA levels in patients who underwent CPR-treated cardiac arrest to achieve main circulation recovery and those who did not achieve spontaneous circulation recovery.

Results: In healthy people, the MDA, SOD and GSH-Px levels in serum are normally distributed. One-way ANOVA shows that the mean MDA levels in the serum of group A1 and group A2 are higher than those of the control group, and both reach statistically significant differences (P<0.05), but there is no statistical difference between group A1 and group A2 (P>0.05); the levels of SOD activity and the average activity level of GSH-Px in serum of group A1 and group A2 are significantly lower than those of normal control group (P<0.05). The IMA level in the serum of group A2 is higher than that of group A1 and normal control group, and there is statistical difference (P<0.05), while the level of IMA in serum of group A1 is higher than that of normal control group. There is also a statistical difference (P < 0.05).

Conclusion: The oxidative stress index in serum can objectively reflect the damage of tissues and organs in patients with cardiac arrest after CPR. The change of IMA level can effectively reflect the ischemic state of tissues and organs in patients with cardiac arrest, and the level of IMA in serum has a certain reference value for effective prognosis of patients with CPR.