Fei Xiao*,#, Juan Mao**


*Department of Gastroenterology, Shanghai East Hospital of Tong Ji University, Shanghai 200120, PR China - **Department of General Medicine, Shanghai Ying Bo Community Health Service Center, Shanghai 200125, PR China


Introduction: Gastroesophageal reflux-related cough cannot be well-treated with proton pump inhibitor (PPI) alone. This study aims to evaluate the differences of the curative effect of two drug on treating gastroesophageal reflux-related cough.

Case presentation: A randomized controlled trial design was used. Ninety patients with repeated cough, accompanying with heartburn, retrosternal pain, acid regurgitation and food regurgitation, were randomly assigned into two groups: experimental group and control group. These patients were orally given 20 mg of omeprazole bid or 20 mg of omeprazole bid + 5 mg of mosapride citrate dispersible tablets tid, with a course of treatment of 12 weeks. Then, the cough symptom score and reflux disease questionnaire (RDQ) score were determined. There were significant differences in cough symptoms scores and RDQ scores between the experimental group and control group before and after treatment (P<0.05). The cough symptom scores in the experimental group decreased by 1.29 ± 0.19, while the decreased value in the control group was 0.63 ± 0.38, and the difference between these two groups was statistically significant (P=0.038). The RDQ scores in the control group decreased by 3.55 ± 0.39,  while the decreased value in the experimental group was 6.22 ± 0.90, and the difference between these groups was statistically significant (P=0.027).

Conclusion: The results of the present study showed that the scores of these two groups after treatment significantly improved, when compared to those before treatment. These findings indicate that PPI combined with prokinetic agents has a good effect on gastroesophageal reflux-related cough. This study confirmed the effectiveness and worth popularizing in the treatment of acid-suppressing and gastrointestinal motility drugs. However, in terms of mental factors, sleep disorders, lifestyle and many other factors, it has not been further explored and involved, and needs other research.


cough, gastroesophageal reflux disease, proton pump inhibitors, prokinetic agents, difference.