Authors

Shan Liu*,**, Jie liu***, Jia Lu*, Junyu Xiong***,#

Departments

*Dalian Medical University, Dalian, Liaoning 116027, P.R. China - **Department of Critical Care Medicine, The Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, Liaoning 116027, P.R. China - ***Department of Anesthesiology, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China

Abstract

Objective: To evaluate the Value of Presepsin (soluble CD14 subtype) Combined with blood lactic acid (Lac), SOFA Score in Evaluating the Prognosis of Sepsisthe.  

Methods: From May 2017 to September 2018, 138 patients with sepsis admitted to ICU of our hospital were selected and divided into survival group (88 cases) and death group (50 cases) according to the mortality rate within 28 days. The general data of patients were collected and the changes of serum Presepsin, Lac and SOFA scores in the two groups were detected and compared. Multivariate Logistic regression was used to analyze the influencing factors of 28d mortality. ROC curve was used to analyze the value of serum Presepsin, Lac, SOFA score alone or in combination in evaluating the prognosis of sepsis. 

Results: Serum Presepsin, Lac levels and SOFA scores of patients in the death group were significantly higher than those in the survival group, with statistically significant differences (P<0.05). Multiariable Logistic regression analysis results show that the APACHE Ⅱ score, serum Presepsin, Lac, SOFA score are the influence factors of sepsis patients with 28d case fatality rate (P < 0.05); The results of ROC curve analysis showed that the area under the curve (AUC) of serum Presepsin, Lac and SOFA scores were 0.889, 0.812 and 0.819, respectively, with sensitivity of 81.0%, 78.1% and 75.8%, and specificity of 92.4%, 88.3% and 87.2%, respectively. The AUC of combined detection was 0.928, significantly higher than that of independent detection (P<0.05).

Conclusion: Serum Presepsin, Lac, SOFA score, Sepsis, The prognosis.

Keywords

Serum Presepsin, Lac, SOFA score, Sepsis, The prognosis.

DOI:

10.19193/0393-6384_2019_6_520