Authors

Cambrea Simona Claudia*,**#, Popescu Gilda Georgeta**#, Resul Ghiulendan**, Petcu Lucian Cristian****

Departments

*Faculty of Medicine, “Ovidius” University, Constanta, Romania -**Clinical Infectious Diseases Hospital, Constanta, Romania - ***Faculty of Medicine, “Titus Maiorescu” University, Bucharest, Romania - ****Faculty of Dentistry, “Ovidius” University, Constanta, Romania

Abstract

Introduction: Although there is a declining in infectious diseases mortality all over the world, there is still no area on the globe were mortality rate completely disappeared through these diseases. Despite available vaccination, there are still challenges related to various infectious diseases such as enterocolitis, tuberculosis, malaria or infection with human immunodeficiency virus (HIV). 

Materials and methods: Analysis of death causes based on clinical, biological and anatomo-pathological examinations was performed among patients admitted in Constanta Clinical Infectious Diseases Hospital, from January 2008 to December 2017, by their HIV status. 

Results: In a period of 10 years, in Constanta Clinical Infectious Diseases Hospital, 184 inpatients died. Mostly deaths were related with HIV infection/AIDS (n=134; 72.82%), while others (n=50; 27.18%) were caused by other infectious diseases among non-HIV infected patients. The mean age of HIV group was 31.72 years +/-13.458, versus 56.27 years +/- 21.114 in non-HIV group. The risk of death in HIV group was 6.43 times higher for tuberculosis (OR = 6.43), 12.135 higher for candidiasis (OR = 12.135) and 3.84 times higher for respiratory infections (OR = 3.845), 6.99 lower for cardiovascular disease (OR = 0.143) and 2.48 lower for sepsis (OR = 0.402) compare to non-HIV group. The risk of death was equal between groups regarding liver cirrhosis, and brain infections. 

Conclusion: We found a higher risk of death by candidiasis, tuberculosis, or respiratory infections and a lower risk of death by cardiovascular disease or sepsis in HIV group comparative with non-HIV group of patients. Therefore, it is very important to know the main conditions that can influence the mortality rate of HIV and non-HIV patients because the proper management of these conditions can reduce the risk of mortality.

Keywords

mortality, HIV, tuberculosis, respiratory infections, malignancies.

DOI:

10.19193/0393-6384_2019_6_554