Authors

Yanping Ma*,#, Yuanming Lu**, Qiaoli Song***

Departments

* Department of Geriatrics, People's Hospital, Chengyang District, Qingdao, Shandong, China - **Department of Neurology, The first People's Hospital of Guangyuan, Sichuan Province - ***School of Nursing, Zhangjiakou University, Hebei Province

Abstract

Objective: To investigate the changes of serum Hcy, CysC, hs-CRP, ET-1, and FIB levels in patients with primary cerebral infarction (CI) and their relationship with the occurrence and development of the disease.

Methods: 78 cases with primary CI admitted to Department of Neurology in our hospital from June 2015 to October 2016 were selected as the observation group, and 80 healthy subjects of physical examination in the outpatient department of our hospital were selected as the control group in the same period. According to the results of cephalic CT, 78 patients with primary cerebral infarction were divided into three groups: there were 23 cases of small area cerebral infarction in group A, 28 cases of medium area cerebral infarction in group B, and 27 cases of large area cerebral infarction in group C. The concentrations of serum Hcy, CysC, hs-CRP, ET-1, and FIB in patients of group A, B and C were compared. At the same time, 78 patients with primary cerebral infarction were divided into three groups: mild neurological deficit (n=24), moderate neurological deficit (n=26) and severe neurological deficit (n = 28). The concentrations of serum Hcy, CysC, hs-CRP, ET-1, and FIB in the three groups were compared.

Results: Compared with the control group, the levels of serum Hcy, CysC, hsCRP, ET1, and FIB were significantly increased (P<0.05). There were significant differences in serum Hcy, CysC, hs-CRP, ET-1, and FIB concentrations after pairwise comparison of three groups of patients in group A, B and C (P<0.01), and the increase of the concentrations of plasma Hcy, CysC, hs-CRP, ET-1, and FIB in group C were more obvious (P<0.01). There was an increasing relationship of the concentrations of serum Hcy, CysC, hs-CRP, ET-1, and FIB among the three groups of mild, moderate and severe neurological deficit, and there was a significant difference among the three groups (P<0.01).

Conclusion: The levels of serum Hcy, CysC, hs-CRP, ET-1, and FIB in patients with primary cerebral infarction are closely related to the condition and prognosis of cerebral infarction and play an important role in the occurrence and development of cerebral infarction.

Keywords

Primary cerebral infarction, serum homocysteine (Hcy), cystatin (CysC), high sensitive C-reactive protein (hs-CRP), endothelin-1 (ET-1), fibrinogen (FIB).

DOI:

10.19193/0393-6384_2019_6_516