Zhengzhen Zhao*, Linqiang Hu**,#, Xiaoju Shu*, Tengtao Ling*, Yuan Zhang*, Xiaoyun Deng*, Dongxing Xie*, Kun Zheng*, Wei Li*


*Echocardiography Room, Tangshan Gongren Hospital - 2Five ward of Neurology, Tangshan Ninth Hospital - **Five ward of Neurology, Tangshan Ninth Hospital


Objective: To analyze the correlation between cryptogenic ischemic stroke (CS) and atrial septal dilatation tumor. 

Methods: A total of 55 patients who were diagnosed with ischemic stroke and no clear cause of etiology in our department of neurology from January 2016 to March 2019 were selected as the observation group, in addition, 55 patients of similar age excluding ischemic stroke were selected as the control group. The risk factors of cerebral ischemic stroke in the two groups were collected including coronary heart disease, diabetes, hypertension, smoking and drinking history, blood lipid level and other factors. Echocardiography was used to examine the presence of septal dilatation tumor in the two groups and to compare the incidence of septal dilatation tumor in the two groups. Logistic regression analysis of risk factors affecting CS occurrence. 

Results: The detection rate of septal dilatation tumor in the observation group was 20.00%, which was significantly higher than that in the control group (3.64%, P<0.05). The amplitude of atrial septal swing, right-to-left shunt at rest and right-to-left shunt ratio of contrast agents in the observation group were significantly higher than those in the control group (P<0.05). In the observation group, the peak blood flow velocity and maximum pressure order difference of right and left atria were significantly higher than those of the control group, and the difference was statistically significant (P<0.01). There was no statistically significant difference in the width of the foramen ovale blood stream between the two groups (P>0.05). Logistic regression analysis results showed that among the risk factors of CS, the OR value of atrial septal dilatoma was 3.638, and 95% CI was 1.282~9.078, confirming that atrial septal dilatoma was a risk factor for the incidence of CS in young Chinese patients.

Conclusion: Atrial septal dilatation tumor plays an important role in the pathogenesis of cryptogenic ischemic stroke, and the change of early detection of atrial septal dilatation tumor in young and middle-aged patients is beneficial to the progress of clinical treatment of CS.


Cryptogenic ischemic stroke, septal dilatation tumor, correlation.