Diyan Genov*, Irena Ivanova**, Ventsislava Pencheva***, Atanas Kundurdgiev*


*Clinic of Nephrology, UMHAT “St. Ivan Rilski”, Medical University, Sofia 1000, Bulgaria - **Clinic Laboratory, UMHAT “St. Ivan Rilski”, Medical University, Sofia 1000, Bulgaria - ***Department of propedeutics of Internal Medicine, UMHAT “Alexandrovska”, Medical University, Sofia 1000, Bulgaria


Introduction: Chronic kidney disease is one of the most frequent chronic diseases causing disability and a significant decrease in quality of life. A major role in its diagnosis plays the clinical laboratory because it provides fast, easy and relatively cheap methods. Although there are well-established markers such as serum creatinine and cystatin C, the search for new reliable biomarkers to help assess kidney function and to predict the evolution of the disease continues. One of them can be Uromodulin, also known as Tamm-Horsfall protein. However, its exact function still needs to be clarified.

The aim of the study was to evaluate the role of serum uromodulin as a marker of the renal impairment in patients with chronic renal diseases.

Materials and methods: A total of 68 patients were enrolled in this prospective observational study in the Clinic of Nephrology of the University Hospital "St. Ivan Rilski " for a period of two years (2017-2018). The mean age of the patients was 62.21±11.869 years with the male/female ratio 31/37 (45.6% / 54.4%). Laboratory blood and urine tests, abdominal ultrasound with resistive index measurement and serum uromodulin investigations were performed in all patients.

Results: Serum uromodulin levels were significantly negatively correlated with serum creatinine (r = -0.720, p <0.0001), urea (r = -0.717, p <0.0001), uric acid (r = -0.296, p = 0.017), cystatin C (r = -0.353, p = 0.004) and resistive index (r = -0.353, p = 0.004). Correspondingly, a positive relationship with estimated glomerular filtration rate (r = 0.692, p <0.0001) was found.

Conclusion: Serum uromodulin levels significantly correlate with the resistive index and all already established laboratory parameters used for evaluation of renal impairment. It can be used as a potential marker for diagnosis and early assessment of chronic kidney disease progression.


serum uromodulin, chronic kidney disease, biomarker, cystatin C, resistive index.