Emircan Erecan*, Elif Yorulmaz**, Bilge Özdemir***, Hatice Yorulmaz****, Can Davutoğlu**
*Department of Internal Medicine, Bagcilar Training and Research Hospital, Istanbul, Turkey - **Department of Gastroenterology, Bagcilar Training and Research Hospital, Istanbul, Turkey - ***Department of Biochemistry, Bagcilar Training and Research Hospital, Istanbul, Turkey - ****School of Nursing, Halic University, Beyoğlu, Istanbul, Turkey
Introduction: Fetuin-A acts as a negative acute phase protein that may also be involved in the pathogenesis of Ulcerative colitis (UC). The aim of this study was to investigate the relationship between serum Fetuin-A levels and clinical and biochemical parameters in patients with UC.
Materials and methods: This study included 40 healthy subjects and 40 patients with UC. Fetuin levels were measured by using ELISA. Haemoglobin, platelet, platelet width distribution (PDW), leukocyte, C-reactive protein (CRP), procalcitonin, total protein, albumin, and sedimentation values were analysed.
Results: Haemoglobin, albumin, and fetuin levels of the control group increased compared to the patient group (p<0.01). Procalcitonin, C-reactive protein (p <0.05), leukocyte, and sedimentation values (p <0.01) were higher in the patient group. Fetuin-A had a negative correlation with sedimentation and leukocyte values (p <0.05).
Conclusion: Fetuin-A level was found to be significantly lower in patients with UC compared to control group. There was a significant negative correlation between leukocyte and sedimentation values and fetuin-A. Fetuin-A level was significantly lower in the left colon and the advanced involvement than the distal involvement. Fetuin-A may be a guide for the involvement site of disease and the inflammation level in UC.
fetuin-A, inflammation, ulcerative colitis.