Yonglin Yang, Bin Li, Zonghong Chang, Shengchao Kang, Qiang Ma, Jiayu Chen, Wei Wang
Department of Gastroenterology, 940th Hospital of the Joint Logistics Support Force of Chinese People’s Liberation Army
Objective: To analyze the expression of Galectin-3 protein in gastric cancer and to explore its correlation with clinicopathological features and prognosis.
Methods: 100 cases of pathological paraffin samples after gastric cancer radical surgery, 100 cases of gastric cancer tissue and 30 cases of 5cm tissue adjacent to the cancer were selected retrospectively from January 2017 to July 2018 in our hospital for digestive surgery. The expression level of Galectin-3 protein was detected by immunohistochemical staining to explore expression level of it in gastric cancer tissues, and analyze its relationship with clinicopathological features and prognosis.
Results: The positive expression rate of Galectin-3 in gastric cancer tissues was significantly higher than that in adjacent tissues (P<0.05) and it was not related to gender, age and differentiation (P>0.05), but there was a correlation between TNM staging, lymph node metastasis, distant metastasis and depth of gastric cancer invasion (P<0.05). In 90 cases of follow-up, 46 cases of recurrence and metastasis (including 35 cases died within 5 years), and 44 cases of no recurrence and metastasis within 5 years. Galectin-3 positive expression patients had more recurrence and metastasis within five years, but less survival more than 5 years. Univariate regression model analysis showed that the 5-year survival rate was associated with Galectin-3 expression, TNM stage, lymph node metastasis, and distant metastasis (P<0.05). Multivariate regression analysis found that Galectin-3 positive expression was considered a independent risk factors the prognosis of patients with bladder cancer (P<0.05).
Conclusion: The positive expression rate of Galectin-3 protein is closely related to TNM stage, lymph node metastasis, distant metastasis and depth of gastric cancer invasion. And as an independent risk factors for the prognosis of patients with bladder cancer, the detection of its level is important for judging the malignant degree of gastric cancer and the prognosis of patients with gastric cancer.
Galectin-3, gastric cancer, clinicopathology, prognosis.