Jian Wang*, Weitao Zhang*, Cangtuo Li*, Guang Song*, Zhibin Zhao**, Shaoxin Yao*,#
*Department of Intervention, Tangshan Gongren Hospital, No. 27 Wenhua Road, Lubei District, Tangshan City, Hebei Province - **Tangshan No.11 Middle School, No. 51 Xinhua East Road, Lubei District, Tangshan City, Hebei Province.
Objective: To explore the effects of Xueshuantong combined with alprostadil on TB, NO and oxidative stress in patients with arteriosclerosis obliterans.
Methods: 82 patients with LEAOS who were treated in our hospital from August 2017 to May 2018 were divided into control group and observation group according to random number table method, 41 cases in each group. The patients in the control group were treated with alprostadil. 20μg alprostadil injection was added into 100ml saline intravenous drip once a day for 4 weeks. The observation group was treated with Xueshuantong on the basis of the control group. 0.5g Xueshuantong was added into 250 ml 10% glucose solution by intravenous drip once a day for 4 weeks. The clinical efficacy and adverse reactions of the two groups were observed. The changes of serum total bilirubin (TB), nitric oxide (NO), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and total antioxidant capacity (T-AOC) were compared between the two groups.
Results: The total effective rate of the observation group was 95.12%, which was significantly higher than 73.17% of the control group (P < 0.05). After treatment, the levels of TB and NO in the two groups were significantly higher than those before treatment (P < 0.05), and the levels of TB and NO in the observation group were significantly higher than those in the control group (P < 0.05). After treatment, SOD, GSH-Px and T-AOC of the two groups were significantly higher than those before treatment, MDA level was significantly lower than that before treatment (P < 0.05), and SOD, GSH-Px and T-AOC of the observation group were significantly higher than those of the control group, and MDA level was significantly lower than that of the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05).
Conclusion: Xueshuantong combined with alprostadil in the treatment of ASO can effectively improve tissue ischemia, hypoxia and microcirculation disorders, reduce the level of oxidative stress, and have good drug tolerance, fewer adverse reactions and higher safety.
Xueshuantong, alprostadil, arteriosclerosis obliterans, TB, NO, oxidative stress.