Authors

Fang Gong*, Yuchan Chen*, Shuyi He*, Man Feng**, Zewei Jiang**, Shilong Xiong***,#

Departments

*Department of ECG, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China - **Department of Ultrasound, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China - ***Department of Clinical Laboratory, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China

Abstract

Objective: To analyze the relationship between serum angiotensin-converting enzyme (ACE), high-sensitivity C-reactive protein (hs-CRP) and brain natriuretic peptide (BNP) levels and the severity of coronary artery stenosis in hypertension.

Methods: A total of 136 patients with hypertension in our hospital from July 2016 to October 2018 were randomly divided into hypertension and coronary heart disease group and hypertension group according to coronary angiography. There were 76 patients in the hypertension and coronary heart disease group, and 60 patients in hypertension group, and at the same time, 65 healthy subjects who underwent physical examination in our hospital during this period in the control group.The results of laboratory tests [SBP, DBP, HDL, LDL], serum ACE, hs-CRP and BNP in different groups were compared, and changes of serum ACE, hs-CRP and BNP in patients with different Gensini scores were measured to analyze the correlation between serum ACE, hs-CRP and BNP levels and the severity of coronary artery stenosis.

Results: SBP, DBP and LDL in the hypertension and coronary heart disease group and the hypertension group were significantly increased, while HDL was significantly decreased compared with the control group (P<0.01),and there was no significant difference in DBP level between the first two groups(P>0.05).The HDL in the hypertension group was significantly higher than that in the hypertension group with coronary heart disease group, conversely the LDL level was significantly lower (P<0.01).The levels of serum ACE, hs-CRP and BNP in hypertension with coronary heart disease group were significantly higher than those in the control group and in hypertension group (P<0.01). Serum ACE, hs-CRP and BNP levels were significantly increased with the increase of Gensini score (P<0.01). Serum ACE, hs-CRP and BNP levels were positively correlated with Gensini score according to Pearson correlation analysis (P<0.05).

Conclusion: Serum ACE, hs-CRP and BNP levels are significantly higher in hypertensive patients than in healthy subjects, and are significantly correlated with the severity of coronary artery stenosis. 

Keywords

Hypertension, ACE, Hs-CRP, BNP, degree of coronary artery stenosis, correlation.

DOI:

10.19193/0393-6384_2019_6_500