Xie Yingjin*, **, Qiu Mingxing*,***,#
*The Affiliated Hospital of Southwest Medical University, Sichuan Province - **Department of Urology Surgery, People's Hospital of Zhongjiang County, Sichuan Province - ***Department of Urology Surgery, Sichuan People's Hospital, Sichuan Academy of Medical Sciences, Sichuan Province
Objective: To investigate the expression of tumor metastasis-associated gene 2 (MTA2) in bladder cancer tissues, and to analyze its correlation with clinicopathological features and prognosis.
Methods: 120 bladder cancer tissue samples of patients who had been accurately diagnosed with bladder canecr and recived urinary surgial operation from Janury 2011 to January 2014, including 80 cases of bladder cancer and 40 cases of paracancerous normal tissues. MTA2 protein was stained and its expression was observed using immunohistochemical staining. The relationship between MTA2 positive expression and negative expression in bladder cancer patients and general clinicopathological features of bladder cancer patients were analzyed. The survival curve of MTA2 protein positive expression and negative expression bladder cancer patients was drew using Kaplan-Meier analysis method. Indicators influencing patient prognosis were analzyed using COX single factor and multivariate risk regression analysis.
Results: The positive expression rate of MTA2 in bladder cancer tissues (87.5%) was significantly higher than that in paracancerous tissues (12.5%) (P<0.05); MTA2 expression was associated with histological grade, TNM stage, lymph node metastasis, and lymphatic invasion in patients with bladder cancer (P<0.05 or 0.01), but not related to patient gender, age, tumor diameter (P>0.05). The 5-year survival rate of patients with positive MTA2 protein expression was significantly lower than that of MTA2 negative patients (P<0.05). The 5-year survival curve of patients drew by Kaplan-Meier analysis showed that MTA2 protein expression and patient prognosis were statistically significant (P<0.05). COX single factor regression model analysis showed that the prognosis of patients was related to MTA2 expression, tissue grade, TNM stage, lymph node metastasis, lymphatic invasion (P<0.05 or 0.01); COX multivariate regression model analysis showed that lymphatic invasion and MTA2 expression were independent risk factors for the prognosis of patients with bladder cancer (P<0.05).
Conclusion: MTA2 protein is highly expressed in bladder cancer tissues. Its expression is correlated with histological grade, TNM stage, lymph node metastasis and lymphatic invasion. The expression of lymphatic invasion and MTA2 are in dependent factors for the prognosis of bladder cancer patients. MTA2 may be a new target for the treatment of bladder cancer.
Bladder cancer, MTA2, Clinicopathological features, Prognosis.