Seydahmet Akin*, Zeki Aydin**, Pinar Özdemir*, Nazire Aladag*, Yasemin Ozgur*, Necmi Eren***
*University of Health Sciences, Dr Lutfi Kirdar Training and Research Hospital, Department of Internal Medicine. Istanbul, Turkey - **Darica Training and Research Hospital, Department of Nephrology. Kocaeli, Turkey - ***Kocaeli University Faculty of Medicine, Department of Nephrology. Kocaeli, Turkey
Introduction: Obesity, hypertension and dyslipidemia are increasing in prevalence worldwide, and are closely linked to cardiovascular diseases. Non-dipper hypertension pattern is associated with more severe target organ damage and cardiovascular events. Atherogenic dyslipidemia has evidence to be an independent risk factor for cardiovascular diseases. There is still not a study made comparing atherogenic dyslipidemia in hypertension patterns. In this study we aimed to compare the prevalence of atherogenic dyslipidemia and dipper, non-dipper hypertension in patients with grade 1 obesity.
Materials and methods: A total of 272 patients (female n:180, 68.2%) with grade 1 obesity followed-up for essential hypertension and who did not have a history of hypolipidemic drug use were included in the study. Patients had atherogenic dyslipidemia, high triglyceride levels, high-density lipoprotein levels and low-density lipoprotein levels were high-normal.
Results: Atherogenic dyslipidemia prevalence was higher in non-dipper hypertension group (n: 84, 67.0%) than patients with dipper hypertension group (n:28, 18.9%) which was also statistically significant (p=0.03).
Conclusion: In our study, the prevalence of hypertension in obese patients was found to be quite high. It is established in our study that atherogenic dyslipidemia may be a factor playing role in non-dipper hypertension patients with grade 1 obesity. Effective treatment of atherogenic dyslipidemia may result in the improvement of non-dipping status. High-risk patients should be evaluated in detail from the cardiovascular end point of view.
Hypertension, Dyslipidemia, Obesity, Non-dipper hypertension.