Yu Zhang, Yuan-Da Zhang, Li-Po Han, Haobin Song


Department of Pediatrics, Baoding Children's Hospital, Key Laborary of Clinical Research on Respiratory Digestive Disease, Hebei Baoding 071000, China


Introduction: HFMD (hand-foot-and-mouth disease)  is an acute intestinal infectious disease. Early discovery, early diagnosis and early treatment have important significance.In this study, we discuss clinical significance of high-sensitivity C-reactive protein (hs-CRP), myocardial zymogram level and the changes of Electrocardiogram in early diagnosis of hand-foot-and-mouth disease (HFMD). 

Case Presentation: 80 child patients clinically diagnosed with HFMD were selected. 39 patients were brought in the severe disease group, and the remaining 41 patients were included in the mild disease group. WBC, hs-CRP, FPG and myocardial zymogram level of all child patients were detected and recorded, and electrocardiogram changes were monitored and recorded.WBC, hs-CRP, FPG, and myocardial zymogram level of severe disease group were higher than that of mild disease group, and the differences had statistical significance (P<0.05). Electrocardiogram change appeared for both groups. Compared with the mild disease group, the heart rate of patients in severe disease group sped up obviously, and anomalous change occurrence rate at ST-T section significantly increased. The differences had statistical significance (P<0.05). 

Conclusion: The hs-CRP, myocardial enzyme level and electrocardiogram detection can early diagnosis, timely treatment, reduce mortality and improve the prognosis of children in the study. Thus, these detection are helpful in the diagnosis of severe HFMD. And it has high clinical value in the early diagnosis of HFMD complicated with myocardial injury.


HFMD, WBC, hs-CRP, myocardial zymogram, electrocardiogram, FPG, early diagnosis.