Authors

Jia Huo*#, Xiu-Ju Huang*, Bahetiguli Yesimuhan*, Li-Sha Guo1, Ye Er Jiang*, Yu-Qing Liu*, Chun ling Lin*, Re He Man*, Yang Zhang**, Zheng-Xian Tao***

Departments

*Department of neurology, Xinjiang Yili Friendship Hospital, Xin Jiang, 835000, China - **Department of endocrinology, Xinjiang Yili Friendship Hospital , Xin Jiang, 835000, China - ***Department of Internal Cardiovascular, Jiangsu Province People's Hospital, Nanjing 210000, China

Abstract

Objective: This study was designed to primarily investigate the clinical and electrophysiological features of impaired glucose tolerance (IGT) patients with peripheral neuropathy (PN) in Han, Hui and Xibe nationalities.

Methods: A total of 300 IGP patients with PN who were treated in the Department of Neurology, Yili Friendship Hospital of Xinjiang Autonomous Region from January 2013 to June 2016 were enrolled into the present study (n=100, each for Han, Hui and Xibe patients).

Results: (1) The proportion of patients with pressure hypesthesia and pallhypesthesia was significantly higher in Xibe nationality patients than in Han and Hui nationality patient, and the differences were statistically significant (P=0.008, P=0.000). (2 Results of the motor nerve conduction in the three groups: the proportion of abnormal amplitude of the lower limbs was significantly higher than that of the upper limbs, and the proportion of abnormal amplitude of the common peroneal nerve was the highest (22%, 26%, 33%, respectively). The proportion of abnormal amplitude of the ulnar nerve amplitude in Xibe nationality patients was compared with that of Han and Hui nationality patients (P=0.002), and the reduction of amplitude of the ulnar nerve and common peroneal nerve was higher in Xibe nationality patients than in Han and Hui nationality patients (P=0.000 and P=0.027). (3) In all three groups, the rate of abnormal amplitude of the sensory nerve was higher than that of the motor nerve: Han, 29.5% (118/400) vs. 14% (56/400), P=0.000; Hui: 28.3% (113/400) vs. 13.8% (55/400), P=0.000; Xibe: 35.8% (143/400) vs. 21.5% (86/400), P=0.000.

Conclusions: The clinical and electrophysiological features of Han, Hui and Xibe nationality patients with IGT and PN mainly manifest as sensory nerve damages, and these clinical and electrophysiological manifestations are more severe in Xibe nationality patients.

Keywords

impaired glucose tolerance, peripheral neuropathy, Neural conduction, racial differences.

DOI:

10.19193/0393-6384_2019_6_494