Authors

Dandan Jiang, Liu Xu#, Dawei Jiang, Lan Shen, Guoliang Wang

Departments

Department of Hepatobiliary Surgery, First Affiliated Hospital of Jiaxing University, Jiaxing, PR China

Abstract

Objective: To analyze the changes and significance of serum chemotactic factor receptor-1 (CMKLR1), monocyte chemokines-1 (MCP-1) and interleukin-8 (IL-8) in patients with type 2 diabetes mellitus complicated with microangiopathy. 

Methods: 96 patients with type 2 diabetes mellitusn treated in our hospital endocrinology department from August 2016 to April 2017 were randomly selected. According to whether the patients were complicated with microangiopathy, they were divided into microangiopathy group and non-microangiopathy group. There were 56 patients in microangiopathy group and 40 patients in non-microangiopathy group. At the same time, 50 healthy subjects examined in our hospital were selected as the normal control group. The levels of serum MCP-1, IL-8, tumor necrosis factor-α (TNF-α), homocysteine (Hcy), CD146 and serum CMKLR1, Chemerin were observed in each group. The correlation was analyzed. 

Results: Compared with the normal control group, the levels of serum MCP-1 IL-8, TNF-α, Hcy, CD146, Chemerin and CMKLR1 in the microangiopathy group and the non-microangiopathy group were significantly higher than those in the non-microangiopathy group, and the above indexes in the microvascular lesion group were significantly higher than those in the non-microangiopathy group (P<0.05). The correlation test of pearson showed that there was a certain correlation between serum MCP-1 and the levels of IL-8, TNF-α, Hcy, CD146, Chemerin and CMKLR1 in patients with type 2 diabetic microangiopathy, and there was a significant positive correlation between them. 

Conclusion: Serum CMKLR1, MCP-1 and IL-8 are involved in the development of microangiopathy in patients with type 2 diabetes mellitus. 

Keywords

Type 2 Diabetic Microangiopathy, CMKLR1, MCP-1, IL-8.

DOI:

10.19193/0393-6384_2019_6_487