Authors

Qiong Li*, Wenrong Song**,#, Lei Zhang***, Zaoxia Pan****, Mingyan Ding*****, Baochang Luo******

Departments

*Internal Medicine-Cardiovascular, Hanchuan People’s Hospital, Hubei Province, Hanchuan City, China - **Department of Endocrinology, Hanchuan People’s Hospital, Hubei Province, Hanchuan City, China - ***Department of Orthopaedics, Hanchuan People’s Hospital, Hubei Province, Hanchuan City, China - ****Department of Neurology, Hanchuan People’s Hospital, Hubei Province, Hanchuan City, China - *****Department of Anesthesiology, Hanchuan People’s Hospital, Hubei Province, Hanchuan City, China - ******Department of Neurosurgery, Hanchuan People’s Hospital, Hubei Province, Hanchuan City, China

Abstract

Objective: To analyze the changes and correlation of serum secreted frizzled-related protein 5 (SFRP5), Humanin (HN), and soluble CD40L (sCD40L) expression in patients with coronary heart disease (CHD).

Methods: From March 2017 to December 2018, 157 patients who underwent coronary angiography in our hospital were divided into 73 patients with acute coronary syndrome, 40 patients with stable angina pectoris, and 44 patients with normal coronary angiography or coronary artery stenosis less than 50% as a control group. General data of all subjects were collected, and all patients were detected by ELISA. The serum levels of SFRP5, HN, and sCD40L were measured, the risk factors of coronary heart disease were analyzed by multivariate logistic regression, and the correlation between serum SFRP5, HN, and sCD40L and blood lipid was analyzed by Kendall test.

Results: Compared with the control group, the levels of serum SFRP5, HN, and sCD40L in the acute coronary syndrome group and the stable angina pectoris group were significantly lower, and the levels of sCD40L were significantly higher (P< 0.01), and the levels of SFRP5, HN and sCD40L in the acute coronary syndrome group and the stable angina pectoris group were significantly different (P<0.05). The results showed that serum SFRP5, HN, and sCD40L were independent risk factors for coronary heart disease (P<0.05); serum SFRP5 was positively correlated with HN, negatively correlated with sCD40L, TC, and HDL (P<0.05) but not with other indicators (P>0.05); HN was negatively correlated with sCD40L and positively correlated with TG, TC, HDL, and LDL (P<0.05). 

Conclusion: The changes of serum SFRP5, HN, and sCD40L levels may be one of the mechanisms of the occurrence and development of coronary heart disease, and the three indicators are expected to become new targets of drug therapy for clinical prevention and treatment of coronary heart disease.

Keywords

Coronary heart disease, serum SFRP5, anti-apoptotic polypeptide, humanin, sCD40L, correlation.

DOI:

10.19193/0393-6384_2019_6_518