Authors

Shuyu Li#, Wenjuan Yan, Tao Tan

Departments

Department of Gastroenterology, The Third People's Hospital of Hubei Province, Wuhan, PR China

Abstract

Objective: To analyze the clinical significance of Obestatin, platelet activating factor (PAF), M30 and M65 levels in patients with severe acute pancreatitis. 

Methods: From January 2017 to February 2018 in our hospital patients with digestive internal medicine clinic of SP 82 cases, including 41 patients with MAP for MAP groups, 41 patients with SAP for SAP group, and 41 healthy adults in the physical examination center of our hospital during the same period were the control group. Comparing the changes of the three groups of Obestatin, interleukin 1 (IL-1β), tumor necrosis factor alpha (TNF-α), PAF, M30, M65, and interleukin - 17 (IL-17). 

Results: Obestatin, IL-1β and TNF-α levels in MAP group and SAP group were significantly higher than those in the control group, and Obestatin, IL-1β and TNF-α levels in MAP group were significantly lower than those in SAP group, with statistically significant differences (P<0.05). PAF levels of patients in the MAP group and the SAP group were significantly higher than those in the control group, and PAF levels of patients in the SAP group were significantly higher than those in the MAP group, with statistically significant differences (P<0.05). The serum M30 and M65 levels of patients in the MAP group and SAP group were significantly higher than those in the control group, and the M30/M65 ratio was significantly lower than that in the control group. Obestatin, PAF, M30 and M65 have good specificity and sensitivity in the diagnosis of patients with acute pancreatitis. Obestatin is positively correlated with PFA, M30 and M65 levels in patients with ASP (P<0.05). 

Conclusion: The levels of Obestatin, PAF, M30 and M65 in SAP patients have important diagnostic value in determining the severity of SAP patients, which is conducive to the selection of early treatment measures, effective control of inflammatory response, prevention and treatment of complications, and reduction of mortality. 

Keywords

Severe acute pancreatitis, obestatin, PAF, M30, M65, clinical significance.

DOI:

10.19193/0393-6384_2019_6_488