Authors

Mingde Ni*, Hongbo Qiao**, Quan Li***, Hongmei Liu****, Zhidong Wang*****, Xiuping Li******,#

Departments

*Department of Tuberculosis, Linyi People's Hospital - **Department of Respiration, Linyi People's Hospital - ***Department of Traditional Chinese Medicine, Affiliated Hospital of Weifang Medical University - ****Department of Obstetrics and Gynecology, Linyi Jinluo Hospital, Qianfoshan Hospital, Shandong Province - *****Department of Emergency, Linyi People's Hospital - ******Eastern Division of Surgery, Linyi People's Hospital

Abstract

Objective: To investigate the expression differences of IL-1p, TNF-α, IP-10, MCP-1, MIP-1pin plasma among bronchial tuberculosis patients, pulmonary tuberculosis patients and healthy people.

Methods: From April 2013 to April 2017, 63 cases of bronchial tuberculosis, 67 cases of pulmonary tuberculosis, 65 healthy check-up in our hospital were the research object. Corresponding elisa kits were used to detect the concentration of the IL-1p, TNF-α, IP-10, MCP-1, MIP-1pin plasma of the bronchial tuberculosis, pulmonary tuberculosis, healthy check-up crowd, the detection indexes were analysed by T test and Person correlation analysis about difference and correlation analysis. 

Results: The content of IL-1p, TNF-α, IP-10, MCP-1, MIP-1pin plasma among bronchial tuberculosis patients were higher than healthy check-up crowd, and the various testing indexes had significant difference between two groups (P<0.05). The content of IL-1p, TNF-α, IP-10, MCP-1, MIP-1pin plasma among pulmonary tuberculosis patients were higher than healthy check-up crowd, and the various testing indexes had significant difference between two groups (P<0.05). The content of IL-1p, TNF-α, IP-10, MCP-1, MIP-1pin plasma of bronchial tuberculosis patients were almost as same as pulmonary tuberculosis patients, and the various testing indexes had no significant difference between two groups (P>0.05). The content of IL-1p was positively related with TNF-α in bronchial tuberculosis patients (r=0.903, P=0.018), and The content of IL-1p was positively related with IP-10, MCP-1, MIP-1p (r=0.917, P=0.017; r=0.889, P=0.021; r=0.856, P=0.019). Also, The content of IL-1p was positively related with TNF-α in pulmonary tuberculosis patients (r=0.921, P=0.013), and The content of IL-1p was positively related with IP-10, MCP-1, MIP-1p (r=0.894, P=0.012; r=0.901, P=0.015; r=0.878, P=0.023).  

Conclusion: The contents of IL-1p, TNF-α, IP-10, MCP-1, MIP-1pin plasma of Patients with bronchial tuberculosis and pulmonary tuberculosis all had significant differences with the healthy people. So we could use those indexes as auxiliary indexes when we diagnosed bronchial tuberculosis and tuberculosis to achieve the best treatment period for patients.

Keywords

bronchial tuberculosis, pulmonary tuberculosis, IL-1p, TNF-α, IP-10, MCP-1, MIP-1p.

DOI:

10.19193/0393-6384_2019_6_460