VALUE OF PTEN AND KI-67 IN ASSESSING THE MALIGNANT DEGREE AND PROGNOSIS OF CUTANEOUS SQUAMOUS CELL CARCINOMA

Jianzhong Peng1, Weiguo Feng1, Xianyan Luo1, Tao Wang1, yeqin Dai1, Jingyu zhu2, *

1Department of Dermatology, Hangzhou Third People’s Hospital, 38 West Lake Road, Hangzhou, Zhejiang, 310009 - 2Department of Urology, Hangzhou Third People’s Hospital, 38 West Lake Road, Hangzhou, Zhejiang, 310009

Objective: To investigate the value of PTEN and Ki-67 in evaluating the severity and prognosis of cutaneous squamous cell carcinoma (SCC).

Methods: SCC tissues and adjacent normal skin tissues collected from 64 patients with cutaneous SCC diagnosed in our hospital from February 2014 to May 2017 were assigned into a study group or control group. The expression levels of PTEN and Ki-67 in the two groups were determined by immunohistochemical staining. Additionally, the relationship between the expression levels of PTEN and Ki-67 and the severity and prognosis of SCC was analysed.

Results: The positive expression rate of PTEN was higher in the normal skin tissues than that in the SCC tissues (P<0.05). PTEN had a higher positive expression rate in the well-differentiated SCC tissues than that in the moderately and poorly differentiated tissues (P<0.05); the higher the positive expression rate of PTEN was, the higher the differentiation degree of tissues. The expression rate of Ki-67 was higher in the SCC tissues than that in the normal skin tissues (P<0.05), and the lower the positive expression rate was, the higher the differentiation degree of tissues. There was a negative correlation between PTEN and Ki-67 in SCC.

Conclusions: PTEN is lowly expressed in SCC tissues, and higher positive expression rates of PTEN correlate with higher ma- lignant degrees of SCC. Ki-67 is highly expressed in SCC tissues, and lower positive expression rates correlate with lower malignant degrees of SCC tissues. PTEN is negatively related to Ki-67 in SCC. Abnormal expression of PTEN and Ki-67 can be used as indexes to assess the malignant degree and prognosis of SCC.