LEVOSIMENDAN’S INFLUENCE ON MYOCARDIAL DEPRESSION AND PATIENTS WITH SEPTIC SHOCK

Zhen Fan1, hong Chen1, Jing Yan2, Jianwei Le1, XiaoYang Zhou3, Jianhua Zhu1

1The NingBo First Hospital, No. 59, Liu Ting Street, Haishu District, Ningbo, Zhejiang 315000 - 2Zhe Jiang Hospital, No. 12 Ling Yin Road, Hangzhou, Zhejiang 310013 - 3The NingBo Second Hospital, No. 42 Yongfeng Road, Haishu District, Ningbo, Zhejiang 315000

 Objective: To study the influence of Levosimendan on myocardial depression and patients with septic shock.

Method: A total of 126 cases of septic shock were cured with dobutamine (Dob) (control group, n=63) and Levosimendan (LEV) (observation group, n=63) in our hospital from April 2016 to April 2017. We statistically analysed cardiac parameters, index- es of cardiac injury, heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), scores from Acute Physiology, Age and Chronic Health Evaluation II (APACHE II), the total dosage of noradrenaline (NE), oxygen inhalation time of mechanical ventilation, length of ICU stay, and in-hospital mortality between the two groups before and after therapy.

Result: There was a significant (P<0.05) decline in LVESI and LVEDI and a significant (P<0.05) increase in LVER, CI, SVI and LVSWI among all of the patients 48 h after the treatments. Both LVESI and LVEDI in the observation group were significant- ly lower (P<0.05) than those in the control group. LVEF, CI, SVI and LVSWI in the observation group were significantly higher (P<0.05) than those in the control group. The concentrations of PCT, cTnl, BNP and Lac in the two groups significantly decreased (P<0.05) at 48 h after treatment. The concentrations in the observation group were significantly lower (P<0.05) than those in the control group. All of the patients received significantly higher (P<0.05) scores of MVP and significantly lower (P<0.05) scores of HR and APACHE II at 48 h after the treatments. Patients in the observation group received significantly higher (P<0.05) scores of MVP and significantly lower (P<0.05) scores of HR and APACHE II than did patients in the control group. The total dosage of noradrenaline (NE), oxygen inhalation time of mechanical ventilation, and length of ICU stay in the observation group were sig- nificantly less (P<0.05) than those in the control group. There was no statistically significant (χ2=0.302, P=0.815) difference for in-hospital mortality between the two groups.

Conclusion: LEV could effectively cure the myocardial depression of patients with septic shock and improve their conditions; therefore, LEV could have value in clinical application.