EFFICACY OF BENAZEPRIL COMBINED WITH AMLODIPINE IN THE TREATMENT OF PATIENTS WITH HYPERTENSION AND HEART FAILURE AND ITS EFFECTS ON SERUM ADRENOMEDULLIN, ANGIOTENSIN AND PENTRAXIN 3

Wang Shan-Shan1, gao Chuan-yu2, *

1Department of Hypertension, Zhengzhou University People’s Hospital, Zhengzhou 450003, China - 2Department of Cardiovascular Medicine, Zhengzhou University People’s Hospital, Zhengzhou 450003, China

 Objective: To observe the efficacy of benazepril combined with amlodipine in the treatment of hypertension with heart failure and its effects on serum adrenomedullin, angiotensin, and pentraxin 3.

Methods: Eighty patients with hypertension and heart failure were selected in our hospital from March 2015 to November 2016 and were divided into an observation group (n=40) and a control group (n=40). Patients were treated with benazepril, 10 mg orally, once a day in the control group. In the observation group, patients were treated with benazepril combined with amlodipine, 10 mg orally, once a day. Treatment was continued for 6 months in both groups. The changes in systolic blood pressure, diastolic blood pres- sure and heart rate were observed before and after treatment. The effects of the treatments on serum adrenomedullin, angiotensin and pentraxin 3 were compared.

Results: After treatment, the systolic blood pressure, diastolic blood pressure and heart rate decreased in both groups, showing a statistically significant difference (P<0.05). The blood pressure and heart rate measurements of patients in the observation group were significantly different from those of the control group (P<0.05). The total effective rate of the observation group was 95%, which was higher than that of the control group (77.5%), and this was a statistically significant difference (P<0.05). The levels of serum adrenomedullin, angiotensin and pentraxin 3 in the two groups were significantly lower than those before treatment in the same group (P<0.05). The levels of serum adrenomedullin, angiotensin and pentraxin 3 in the control group were lower than those in the observa- tion group, and the difference was statistically significant (P<0.05).

Conclusion: Benazepril combined with amlodipine is effective for reducing the blood pressure of patients with hypertension and heart failure. Simultaneous lowering of serum adrenomedullin, angiotensin and pentraxin 3 levels could improve cardiac function and be worthy of clinical promotion.