EFFECT OF TONGXINLUO CAPSULE COMBINED WITH METOPROLOL ON PRIMARY HYPERTEN- SION AND CORONARY HEART DISEASE, INFLUENCE ON HOMOCYSTEINE AND ENDOTHELIAL FUNCTION IN PATIENTS

ShuBei Yu*, XiXi Lin, LiMan Qiao, Yi Zheng

The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 32500

 Objective: To investigate the effect of Tongxinluo capsule combined with metoprolol on primary hypertension and coronary heart disease, influence on homocysteine and endothelial function in patients.

Methods: A total of 128 cases of patients with primary hypertension and coronary heart disease admitted in our hospital from January 2016 to January 2018, were randomly divided into the observation group and the control group with 64 cases each group. The observation group was given Tongxinluo capsule combined with metoprolol, the control group was treated with metoprolol,the treatment lasted for 14d.

Results: The total effective rate of observation group was 92.19%, the control group was 75%, the observation group was sig- nificantly better than the control group (P<0.05). The systolic pressure and diastolic pressure levels of two groups were significantly improved after treatment (The observation group: t=19.5375, 16.4710, The control group: t=12.6305, 7.7504, P<0.05). The systolic pressure and diastolic pressure levels of observation group was significantly lower than the control group (t=8.8298, 8.1838, P<0.05). After treatment. The incidence and duration of angina in two groups were significantly lower, (the observation group: t=20.2237, 23.7450, the control group: t=19.8862, 14.8211, P<0.05). The incidence and duration of angina in the observation group was signif- icantly lower than the control group.(t=13.5451,15.4837, P<0.05). After treatment, homocysteine levels of two groups were signifi- cantly lower(the observation group:t=21.1313, the control group: t=9.0159, P<0.05). Homocysteine levels of the observation group was significantly lower than the control group (t=12.7706, P<0.05).After treatment, ET-1 level reduce when NO level increase (the observation group: t=32.3946, 27.9182, the control group: t=14.1317,13.6478, P<0.05);ET-1 level of the observation group was lower than the control group, when NO level of the observation group was higher than the control group(t=18.4665,12.7838, P<0.05).

Conclusion: The effect of Tongxinluo capsule combined with metoprolol on primary hypertension and coronary heart disease has greater clinical benefit. It can reduce the homocysteine level and improve endothelial function, which has important research value.