CORRELATION BETWEEN THE PROLIFERATION MARKERS P63, BCL-2, PCNA, KI-67 AND MCM2 AND CLINICOPATHOLOGY AND PROGNOSIS IN AMELOBLASTOMA

Min Zhang1, Yuan Tian2, Wei Zu2, haijie guan3, ning Ruan4, Wenchao Li2

1Orthodontics Department, Chifeng University Affiliated Hospital of Inner Mongolia, Chifeng, 024000 - 2Oral Implant Department, Chifeng University Affiliated Hospital of Inner Mongolia, Chifeng, 024000 - 3Endodontics Department, Chifeng University Affiliated Hospital of Inner Mongolia, Chifeng, 024000 - 4Nursing Department, Chifeng University Affiliated Hospital of Inner Mongolia, Chifeng, 024000

Objective: To investigate the relationship between P63, Bcl-2, PCNA, Ki-67 and MCMC2 and clinicopathology and prognosis in ameloblastoma (AB).

Methods: Fifty-two samples of ameloblastoma patients with tumour tissue and 20 samples of normal gingival tissue were select- ed; all samples were from patients enrolled and diagnosed in our hospital from Dec. 2004 to Dec. 2014. The expression of P63, Bcl-2, PCNA, Ki-67 and MCM2 in ameloblastoma and normal gingival tissue was assessed by immunohistochemical examinations. Data were analysed combined with pathological type, capsular invasion and prognosis in ameloblastoma.

Results: (1) Compared with the normal group, the expression levels of all proliferation markers were significantly different from that in ameloblastoma (P<0.05). (2) P63 was significantly different (P<0.05), but Bcl-2 and PCNA were not (P>0.05), between different pathological types, capsular invasion and the recurrence of ameloblastoma. (3) The expression of Ki-67 and MCM2 in dif- ferent pathological types and the recurrence of ameloblastoma were significantly different (P<0.05), but Ki-67 and MCM2 showed no significant difference in different capsular invasion (P>0.05).

Conclusion: The expression of P63 is closely related, as is Bcl-2, while PCNA has no correlation to the pathological type, cap- sular invasion and recurrence of ameloblastoma. The expression of Ki-67 and MCM2 show a direct correlation with different patho- logical types and the recurrence of ameloblastoma, but there was no correlation with different capsular invasion of ameloblastoma.