CHANGES IN HTERT, VEGF, RET AND P53 EXPRESSIONS IN THYROID CARCINOMA PATIENTS

Lina Yao1, #, Kun Zhang1, #, Junsheng gu2, ge Zhao3, MengJie Ding4, shaoxuan Wu4, ZhenZhen Yang4, MiJing Ma4, Meifeng Yin4, Wanqiu Yang5, Linan Zhu4

1No.1 Ward of Internal Medicine, Henan Electric Power Hospital, Zhengzhou, Henan, China, 450000 - 2Division of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China, 450000 - 3Pediatric Surgery, The East District of the First Affiliated Hospital of Zhengzhou University Zhengzhou, Henan, China, 450000 - 4Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China, 450052 - 5The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China, 453003

 Objective: To study the expressions of telomerase reverse transcriptase (hTERT), vascular endothelial growth factor (VEGF), Ret and P53, and their relationship to various pathological factors in different pathological types of thyroid carcinoma (TC) patients. Method: Paraffin-embedded pathological specimens of thyroid carcinoma (174) and 40 normal hypothyroid tissue specimens

preserved in the Pathology Department from July 2012 to June 2017, were used in the study. The expressions of hTERT, VEGF, Ret and P53 were assayed using immunohistochemical staining in order to analyze their association with pathological types, ages, tumor diameters, lymphatic metastasis and TNM tumor stage of the TC patients.

Results: The expressions of hTERT, VEGF, Ret and P53 were 79.89, 78.16, 70.69 and 81.03%, respectively, and significantly higher than the corresponding expressions in normal hypothyroid tissue (p<0.05). The positive expressions of hTERT and VEGF were associated with tumor diameter, while VEGF and Ret expressions were related to lymphatic metastasis; hTERT, VEGF, Ret and P53 expressions were associated with TNM tumor stage (p<0.05). However, there was no association between the expressions of hTERT, VEGF, Ret and P53, and age and tumor pathology (p>0.05).

Conclusion: The increased positive expressions of hTERT, VEGF, Ret and P53 in thyroid carcinoma are of clinical significance, and can aid in early diagnosis of thyroid carcinoma.