CHANGES AND CORRELATIONS OF CRP, COAGULATION INDEXES AND BLOOD GLUCOSE LEVELS IN PATIENTS WITH SEVERE PNEUMONIA COMPLICATED BY SEPSIS

Tong Yiqing, Tang Jianguo*

Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People’s Hospital, Fudan University; Shanghai 200240, PR Chin

 Objective: Recent studies show that the number of excised lymph nodes is an independent prognostic factor for colorectal cancer. Based on this Objective: To investigate the changes in C-reactive protein (CRP), coagulation parameters and blood glucose as well as their correlation in severe pneumonia patients with sepsis.

Methods: A total of 78 severe pneumonia patients with sepsis admitted to our hospital from January 2016 to November 2017 were enrolled in the study. The patients were assigned to an extremely serious group (n= 24), a serious group (n= 32), and a nonserious group (n= 22) according to their course of disease. The levels of serum inflammatory cytokines, such as interleukin-6 (IL-6), interleu- kin-10 (IL-10) and CRP; coagulation parameters, such as P-selectin and D-dimer; and blood glucose and lactate were determined in the three groups to analyze the correlation between their changes and the critical illness score in severe pneumonia patients with sepsis.

Results: The levels of serum IL-6, CRP, P-selectin, D-dimer, blood glucose and blood lactate were much higher in the extremely serious group than those in the serious group and the nonserious group, with a significant difference (P<0.05). The levels of serum IL-6, CRP, P-selectin, D-dimer, blood glucose and lactate were much higher in the serious group than those in the nonserious group, and the difference was statistically significant (P<0.05). The level of IL-10 was much lower in the extremely serious group than that in the other two groups, with a statistically significant difference (P<0.05), and it was much lower in the serious group than that in the nonserious group (P<0.05).

Conclusions: With the worsening of severe pneumonia with sepsis, the levels of IL-6, CRP, P-selectin, D-dimer, blood glucose, and blood lactate increase, whereas the level of IL-10 decreases. In addition, IL-6, CRP, P-selectin, D-dimer, blood glucose and lactate are positively related to the critical illness score, IL-10 is negatively associated with the score, and CRP is not correlated with the score.