RELATIONSHIP BETWEEN SERUM LP-PLA2, MIP-1Α AND MIF LEVELS AND PROGNOSIS IN PATIENTS WITH CORONARY HEART DISEASE

YANG ZICONG, LIN YINGZHONG, YUAN JUN, SHI YING, LIU YU, LU ZHENGDE, XUE YAN, LIU LING

Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Province, 530021, China

Objective: To investigate the relationship between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2), macrophage inflammatory protein-1α (MIP-1α) and macrophage migration inhibitory factor (MIF) levels and prognosis in patients with coronary heart disease.

Methods: 270 patients, admitted from March 2014 to March 2017, were divided into a normal group (n = 65), a single-vessel lesion group (n = 70), a double-vessel lesion group (n = 70) and a triple-vessel lesion group (n = 65). The Gensini score method was used to assess the condition of patients with coronary heart disease. Serum Lp-PLA2, MIP-1α and MIF levels were determined by enzy- me-linked immunosorbent assay (ELISA). Pearson’s correlation was used to analyse the correlation between the Gensini score and serum Lp-PLA2, MIP-1α and MIF levels in patients with coronary heart disease. Subsequently, multivariate logistic analysis was used to analyse risk factors for coronary atherosclerosis in coronary heart disease.

Results: Compared with the normal control group, the three lesion groups had higher plasma levels of Lp-PLA2, MIP-1α, MIF, TC, TG, LDL-C and CRP (P < 0.05) and lower levels of HDL-C and LVEF (P < 0.05). With the increase of the number of lesions, the levels of p-PLA2, MIP-1α, MIF, TC, TG, LDL-C and CRP increased significantly (P < 0.05), while the levels of HDL-C and LVEF decreased (P < 0.05); Pearson ́s univariate analysis showed that the Gensini score was negatively correlated with HDL-C (P < 0.05) and positively correlated with LDL-C, CRP, Lp-PLA2, MIP-1α and MIF (P < 0.05); Multivariate logistic regression analysis showed that the protective factor for coronary atherosclerosis was HDL-C, while risk factors were LDL-C, Lp-PLA2, MIP-1α and MIF.

Conclusion: Serum Lp-PLA2, MIP-1α and MIF levels are closely related to the prognosis of patients with coronary heart disease, which is important for the prognosis of coronary heart disease.