EXPRESSION OF HELICOBACTER PYLORI ANTIBODY IN PATIENTS WITH PANCREATIC CAN- CER

CHENG GENG¹, XINJIAN XU², XIAOHAN NIE³, DU LU⁴, JIANGANG LI⁵, QILONG CHEN⁶, YISIMAYILI ISIMAYILI·AIMAITI⁷, TUERXUNJIANG TUXUN⁸, XIYAN WANG⁹

¹Department of Panctreatic Surgery, Digestive and Vascular Center, 1st Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China - ²Department of Panctreatic Surgery, Digestive and Vascular Center, 1st Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China - ³Department of Panctreatic Surgery, Digestive and Vascular Center, 1st Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China - ⁴Tumor Hospital of Xinjiang Medical University, Urumqi 830054, China - ⁵Department of General Surgery, 2rd Affiliated Hospital of Xinjiang Medical University, Urumqi China - ⁶Department of Panctreatic Surgery, Digestive and Vascular Center, 1st Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China - ⁷Department of General Surgery,The first people's Hospital of Kashi District, Xinjiang China - ⁸Digestive and Vascular Center, 1st Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China - ⁹Tumor Hospital of Xinjiang Medical University, Urumqi 830054, China

Purpose: To investigate the expression of HP antibody and the relationship between HP infection and risk factors for pan- creatic cancer.

Methods: A total of 138 patients were recruited over a 1-year period for this study. They were divided into two groups: observation (68 patients with pancreatic cancer) and control (70 healthy patients). The observation group consisted of 37 males and 32 females aged between 29 and 67 years (mean age = 55.73 ± 5.67 years), while the control group consisted of 38 males and 32 females aged between 24 and 65 years (mean age = 54.26 ± 5.17 years). Pancreatic cancer was established using surgery, pathological and clinical diagnoses. Specimens from the patients were subjected to immunohistochemistry and Western blotting to determine the expressions of HP antibody and cytotoxin-associated gene A-HP IgG (Cag A-HP-IgG).

Results: The positive expression of HP antibody in the observation group (69.12 %) was significantly higher (p < 0.05) than that of control (48.47 %). The expression of Cag A-HP IgG in the observation group (40.43 %) was also significantly higher (p < 0.05) than that of control (17.65 %), and HP infection in patients with pancreatic cancer was closely related to smoking and history of chronic pancreatitis, both of which acted synergistically.

Conclusion: Helicobacter pylori contributes to the development of chronic pancreatitis which can ultimately lead to pan- creatic cancer.