CORRELATION BETWEEN HYPERLIPEMIA WITH HYPERURICEMIA AND CORONARY ARTERY LESION

TIEZHENG WANG, CHUANTAO SUO, HAOWANG

Daqing Oilfield General Hospital, Heilongjiang Daqing, 163001, China

Purpose: To explore the value of hyperlipemia with hyperuricemia in the assessment of coronary artery lesion and in the risk assessment of patients with coronary heart disease.

Methods: This study was performed on 312 cases of clinically suspected coronary heart disease. The patients were divided into 4 groups as follows: hyperuricemia (U), hyperlipemia and hyperuricemia (LU), hyperlipemia (L), and non-hyperlipemia and non-hyperu- ricemia (N). All included patients were divided into a coronary heart disease (C) group and a noncoronary heart disease (NC) group according to the results of coronary arteriography, and the severity of coronary artery lesion was evaluated according to the Gensini scoring criteria. Single and multiple regression analyses were conducted on relevant factors in coronary heart disease via logistic regression analysis. The correlation of hyperlipemia with hyperuricemia and the severity of coronary artery lesions was analyzed by the Trend Test.

Results: The prevalence of both hyperuricemia (65.1%) and hyperlipemia (69.9%) in the C group exceeded that in the NC group (P < 0.05). Hyperlipemia and hyperuricemia are meaningful predictors of coronary heart disease. There are interactions between hyper- lipemia and hyperuricemia. The odds ratio for the interaction of hyperlipemia with hyperuricemia was 1.31. Coronary heart disease patients with hyperlipemia and hyperuricemia scored significantly higher according to the Gensini criteria. There was a trend toward a relationship between hyperlipemia with hyperuricemia and the number of diseased coronary arteries.

Conclusion: There is clinical significance in evaluating coronary artery lesion and disease risk with the joint use of serum uric acid and blood fats.