COMPARISON OF PROPOFOL VERSUS SEVOFLURANE ON THE OUTCOMES OF PATIENTS UNDERGOING CARDIAC SURGERY WITH CARDIOPULMONARY BYPASS

SHAOQUN TANG¹, FANG YANG², KUN ZHANG³, WEI CHEN⁴, TAO XIE³

¹Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China - ²Department of Clinical Oncology,Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China - 3Department of Anesthesiology, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, Hubei, 434020, P. R. China - ⁴Department of Anesthesiology, The first people’s hospital of Jingzhou, The first Clinical Medical College, Yangtze University, Jingzhou, Hubei, 434020, P. R. China

Objective: To compare the effects of propofol versus sevoflurane on the outcomes of patients undergoing cardiac surgery with car- diopulmonary bypass (CPB).

Methods: 110 patients who underwent cardiac surgery with CPB from January 2015 to June 2017 in our hospital were randomly divided into 2 groups (n=55): A group in which anesthesia was maintained with sevoflurane and B group in which anesthesia was main- tained with propofol. MMSE score before and after operation, perioperative laboratory index, the incidence of postoperative cognitive dysfunction (POCD) and the incidence of adverse events between two groups were compared.

Results: MMSE score was significantly higher in B group than in A group after anesthesia (p<0.05). Serum levels of brain injury markers neuron-specific enolase, S100β and matrix metalloproteinase 9 were significantly lower in B group than in A group (p<0.05). POCD incidence at 12 h and 24 h after operation was significantly lower in B group than in A group (p<0.05). There was no significant difference in the incidence of low cardiac output and thoracotomy bleeding between two groups.

Conclusion: Compared with sevoflurane, the use of propofol during cardiac surgery with CPB can efficiently improve postopera- tive cognitive function without increasing the risk of adverse reactions.