APPLICATION OF DETECTION OF EOSINOPHILS IN INDUCED SPUTUM IN BRONCHIAL ASTHMA

GAO LI, HAN LI-HONG, MA YOU-FENG

Luoyang Central Hospital Affiliated to Zhengzhou University, Luo yang, 471000

Introduction: To investigate the correlation of changes of eosinophils in induced sputum with pulmonary function in patients with bronchial asthma before and after treatment.

Materials and methods: Thirty patients with acute exacerbation of bronchial asthma treated in our hospital between January 2018 and March 2018 were randomly selected as observation group. Eosinophils in the induced sputum were detected at acute exacerbation and after treatment using flow cytometry, and pulmonary function was determined at different stages. During the same period, 30 healthy individuals undergoing physical examination were included as control group. Eosinophils in the induced sputum were detected, changes of eosinophils in induced sputum in patients with bronchial asthma were compared before and after treatment, and its correlation with pulmonary function was analyzed.

Discussion: Eosinophils in induced sputum in patients with acute exacerbation of bronchial asthma were significantly more than those after treatment and in healthy adults (both P < 0.05), Eosinophils in induced sputum in patients of asthma after treat- ment.were significantly more than those in people who are healthy (P< 0.05). Before and after treatment, changes of eosinophils in induced sputum in patients with bronchial asthma were negatively correlated with changes in predicted value of FEV1% (r = - 0.618, P < 0.05).

Conclusion: Different levels of eosinophils in induced sputum in patients with bronchial asthma before and after treatment can be used as an indicator of airway inflammation in patients with bronchial asthma. The level of eosinophils in induced sputum is negatively correlated with pulmonary function (the severity of pulmonary function) in asthma.