ANALYSIS OF SURVIVAL TIME AND FACTORS THAT INFLUENCE HIV/ MYCOBACTERIUM TUBERCULOSIS INFECTION

YANLI ZHANG, LI WU, FUJIAN LI

Department of Tuberculosis, Baoding hospital for Infectious disease, BaoDing, 071000, China

Objective: To study the survival time for patients with HIV/AIDS complicated with Mycobacterium tuberculosis infection, and factors that influence it.

Methods: HIV patients in Hebei Province from January 2007 to June 2017 were included in this research. These patients either reported or were confirmed through testing, and took part in follow-up. Patients who presented with extra-pulmonary tuberculosis (TB) or TB in previous follow-ups were screened. The Kaplan-Meier product limit method was used to calculate sur- vival rate, and factors that influence the survival time of patients with double infection were analyzed using univariate and multi- variate Cox proportional hazard regression models.

Results: Among 728 patients with double infection, there were 350 cases (48.08 %) and 589 cases (80.90 %) of complica- tion with TB infection within 2 months, 12 months after HIV confirmation. The 1-year survival of HIV/AIDS patients with TB infection was 80.01 %. The date on which TB infection was diagnosed during follow-up was taken as the start date of observation. By the end of November 30th, 2014, 1376 patients were followed-up in 1 year, and 167 cases of death occurred, resulting in a death density of 15.20 /100 people per year. Multivariate Cox proportional hazards regression model analysis showed that age (HR=1.113, 95 % CI: 1.025 - 1.264), non-usage of antiviral treatment (HR = 14.018, 95 % CI: 8.517 - 21.692), and low first count of CD4 + T lymphocytes (HR=1.452, 95 % CI: 1.274 - 2.945) on HIV confirmation, were high risk factors for mortality. The risk of mortality in homosexual transmission infection (HR = 0.476, 95 % CI: 0.203 - 0.695) were lower than risk of mortality from non-sexually transmitted infections.

Conclusion: HIV/AIDS cases complicated with TB occur within 1 year of follow-up after HIV confirmation. Age, non-sexu- ally transmitted infections, non-usage of antiviral therapy, and low first count of CD4 + T lymphocytes are risk factors for death in patients with double infection.