PREPARATION OF LIPOSOME ENCAPSULATED PROTEIN DRUGS AND CONTROL OF INFLUENCING FACTORS

LIXIN LAN, QUAN ZHOU, XIAOHUI YANG

Department of Pharmaceutical and Biological Engineering, Hunan Chemical Vocational Technology College, Zhuzhou, 412004, China

Objective: Liposome was firstly measuredby electron microscopy in 1965, and was firstly used as drug carrier in 1971. In the lastfew decades, the related studies were mainly focused on using liposome as the carrier of small molecule chemical drugs. In recent years, with the continuous development of biopharmaceutical technology, the studies on using liposome as the carrier of the protein drugs are constantly deepened. The application of protein drugs in clinical diagnosis or treatment shall take account of two aspects, namely whether there are sufficient drugs for the organism to intake and use, and the second aspects is whether the protein drug deli- very is targeted and efficient. Based on this, this paper probed into the previous studies that were carried out in recent years on the liposomes for encapsulating protein drugs. Hence, this study summarized the characteristics of liposome from different preparation methods, and explored the goodpreparation methods to improve the drug entrapment efficiency as well as the excellentdetection method.Thus,this investigation is providing the theoretical basis up to some extent for the industrial production of protein drug lipo- somes.