EFFECT OF BUSHEN JIANPI HUOXUE RECIPE ON TIBIAL STRESS INJURIES IN RABBITS

KUN LIU

School of Physical Education, Soochow University, Suzhou 215021, China - 2PE Department of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China

The study was aimed to study the preventive effect of Bushen Jianpi Huoxue recipe on tibial stress injury in rabbits. In this research, seventy mature male rabbits were divided randomly and equally into 7 groups with each group containing 10 rabbits. All the mature male rabbits were participated in the passive running and jumping before they undergone the radio nuclide bone imaging and tibial X-ray findings. The histological and electron microscopic changes were observed, and each of the parathyroid hormone (PTH), osteocalcin (BGP) and testosterone concentration (T) was measured. After 2 weeks of continuous stimulation, the trends of stress injury in osteocytes, serum parathyroid hormone and osteocalcin have increased, while serum testosterone is showing an obvious decreasing trend. After three to four weeks, the X-ray, radionuclide bone imaging, histology, and blood biochemistry were carried out on the rabbits. The results showed stress injuries have occurred in the rabbits. In the two medication groups, the X-ray and nuclide bone showed the formation of new bone in the cortex; osteoblastic phase existed in bone cells; serum parathyroid hor- mone decreased significantly; while serum osteocalcin and blood testosterone level of the rabbits were higher as compared to exerci- se group in the same week. It can be concluded that Bushen Jianpi Huoxue recipe can be used to treat the tibial stress injury in rab- bits effectively by stimulating the new bone formation and enhance the blood testosterone level.