RELATED RESEARCH ON HEMORRHAGIC TRANSFORMATION CAUSES DETERIORATION AFTER THROMBOLYTIC THERAPY IN PATIENTS WITH ACUTE ISCHEMIC STROKE

HONGLIANG GE1#, FENGJUN CAO1#, GUANJUN SUN1, XIUYUN SHI2, FUBAO JIA1*

¹Department of internal neurology, Shanxian Central Hospital, Shanxian 274300, China - ²Department of Test, Shanxian Central Hospital, Shanxian 274300, China

Object: To investigate hemorrhagic transformation caused by thrombolytic therapy in acute ischemic stroke patients whether can cause disturbance of consciousness and other deterioration.

Methods: Selecting the medical records of acute ischemic stroke patients admitted to Neurology Emergency department in our hospital to retrospectively analysis. The experimental group was 100 patients treated with thrombolytic therapy and hemor- rhagic transformation occurred, and the control group was 100 patients treated with thrombolytic therapy and hemorrhagic trans- formation no occurred. The PT, APPT, FBG indicators of patients before and after thrombolytic therapy were tested, and the serum glutamic acid and serum complement C3 levels were measured after thrombolytic therapy. Then the follow-up work was carried out, and prognostic status of the patients were evaluated by the GOS scoring system.

Results: The levels of PT, APPT, FBG of patients in the experimental group was significantly higher than that of the control group (p<0.05). The serum glutamic acid and serum complement C3 levels of patients in the experimental group was higher than that of the control group (p<0.05). When the GOS score was 4-5, the number of patients in the experimental group was significantly lower than that of the control group, and when the GOS score was 1-3, the number of patients in the experimental group was significantly higher than that of the control group (p<0.05).

Conclusion: Hemorrhagic transformation in acute ischemic stroke patients after thrombolytic therapy will reduce the patient’s prognosis, and seriously threaten the patient's quality of life. We should strictly control the occurrence of the related danger when patients are treated with thrombolytic therapy.