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You are here: Archive 2018 Medica 6 Pag 1739

EFFECT OF ARCTIIN ON RAT HYPERURICEMIA MODEL

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Authors

BAIMING LOUXIN, FANGXIAOYAN. MIAOYANYAN, MIAOMINGSAN

Departments

Henan University of Traditional Chinese Medicine zhengzhou 450046, China

Abstract

Objective: To observe the effect of arctiin on rat hyperuricemia model, and to explore the intervention effect and mechanism of arctiin on hyperuricemic nephropathy.

Methods: Adopt the method of adenine and ethambutol joint application to establish the rat model of hyperuricemia.

Conclusion: Arctiin can significantly reduce serum uric acid(UA), creatine (Cr), Urea nitrog en (BUN), Tumor necrosis factor-α(TNF-α), Mononuclear chemotactic protein -1 (MCP-1) level, xanthine oxidase (XOD) activity, the level of cyclooxyge- nase -2 (COX-2) in the renal tissue homogenate,and it can significantly reduce the degree of pathological injury of the thymus, spleen and kidney tissue. Results: Arctiin is effective for the treatment of hyperuricemia.

Keywords

Hyperuricemic nephropathy, Animal model,Adenine, Ethambutol.

DOI:

10.19193/0393-6384_2018_6_266

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