CORRELATION OF HER2 STATUS WITH HORMONE RECEPTORS ESTROGEN, PROGESTERONE RECEPTORS AND HISTOPATHOLOGIC FEATURES IN INVASIVE BREAST CARCINOMAS: A STUDY ON 117 CONSECUTIVE PATIENTS

ALI KOYUNCUER

Department of Pathology, Hatay State Hospital, Hatay, Turkey

Objective: Nowadays, Estrogen Receptor (ER), Progesteron Receptor (PgR) and HER2 Receptor are commonly used mark- ers in breast cancer (BC). Multifactorial features, chemical or molecular variety of conditions significant differences ethnic group or racial predilection.

Methods: A total of 117 patients suffering from primary malignant invasive BCs was evaluated. ER, PgR and HER2 condi- tions are evaluated by the immunohistochemistry method as a routine for all cases of BC, where paraffin blocks of the cancer are exist.

Results: Although the mean age at the time of diagnosis was 51years, ≥40 years of age comprised 96 (82.1%) of cases, 96 (82.1%) were observed invasive breast carcinoma no special type, mean diameter of tumor size 22.2 millimeters, the majority of breast carcinomas cases (47%) have a histologic grade 2, predominantly pathologic stage; pT1c: 43 (36.8%), most positive lymph node; pN1a: 22 (18.8%) identified. There was strong positive staining in ER, PgR and HER2 37.6%, 19.7%, and 21.4% of the cases, respectively. Triple negativity cases was found 25.67%. The presence of tumor size was associated with lymph-vascular invasion and lymph nodes status (P= 0.01, 0.044, P < 0.05).A significant relationship was found between positive ER staining and lymph-node status (P = 0.013). A significant relationship was found between positive HER2 staining and lymph-vascular invasion and tumor focality (P = 0.041, 0.044).

Conclusion: These results show highly different disease, it varies amongst racial or ethnic predilatation. No statistically significant correlation was found between ER and PgR expression and HER2 staining. No association was found between the HER2 expression and histologic types, histologic grade, tumor size, lymph node status.