School of nursing, Shanghai Jiguang Polytechnic College


Purpose: To investigate the correlation between serum ferritin levels and clinical outcomes of premature coronary artery disease (PCAD) in middle-aged male patients.

Methods: A total of 420 middle-aged male patients with PCAD were recruited with case-control method for this study. The patients were grouped into two based on the cut off serum ferritin (SF) ≥ 200 ng/m: overload group (SF ≥ 200 ng/ml) and control group (SF < 200 ng/ml). Differences between the incidence of major adverse cerebral cardiovascular events (MACCE), carotid atherosclerotic plaques, and survival rate were analyzed.

Results: In one-year follow-up, there were no significant differences (p > 0.05) in the incidence of atherosclerotic plaques, MACCE and survival rate between the two groups. However, in a 3-year follow-up, there was significant difference (p < 0.05) in atherosclerotic plaques between the two groups, but the differences in MACCE and survival rate were not significant (p > 0.05). In a follow-up spanning 5 years, there were significant differences (p < 0.05) between atherosclerotic plaques and MACCE.

Conclusions: High serum ferritin level and iron overload have a positive association with PCAD in middle-aged male patients.


Atherosclerosis, Coronary artery disease, Serum ferritin, Iron overload, Follow-up