ANALYSIS OF EXPRESSIONS AND CLINICAL SIGNIFICANCE OF CXCR1, CXCR2 AND CXCL8 IN PATIENTS WITH PRIMARY HEPATIC CARCINOMA

MIN WEI¹, XIN-HUA LUO¹

Department of Infection, Guizhou Provincial People’s Hospital, Guiyang City, Guizhou Province 550001, China

Purpose: To investigate the expressions and significance of CXC chemokine receptor 1 (CXCR1), CXC chemokine receptor 2 (CXCR2) and CXC chemokine ligand 8 (CXCL8) in primary hepatic carcinoma (PHC).

Methods: A total of 62 PHC patients and 62 CHB patients seen from June 2016 to December 2017 at Guizhou Provincial People’s Hospital, Guiyang City were selected, and randomly divided into PHC group and CHB group. The control group consist- ed of 62 randomly selected healthy people (62, normal group). The mRNA expressions of CXCR1, CXCR2 and CXCL8 were deter- mined in the three groups using real-time fluorescent quantitative method in peripheral blood mononuclear cells (PBMC). The correlation of mRNA expression of CXCL8 with those of CXCR1 and CXCR2 were analyzed by Pearson linear correlation analy- sis, while the predictive values of mRNA expressions of CXCL8, CXCR1 and CXCR2 for PHC were analyzed by ROC curve.

Results: In the PHC group, the mRNA expressions of CXCR1, CXCR2 and CXCL8 were higher than in CHB group and nor- mal group, and in the CHB group, the mRNA expressions of CXCR1 and CXCR2 were higher than those in the normal group (p < 0.05). The mRNA expression of CXCL8 was positively correlated with those of CXCR1 and CXCR2 (r = 0.694, 0.704; p <0.05). For the prediction of PHC, ROC curve model showed that the area under curve of mRNA expressions of CXCR1, CXCR2 and CXCL8 were 0.864, 0.852 and 0.887, respectively; the sensitivities were 0.871, 0.855 and 0.887 respectively; and the specificities were 0.871, 0.839 and 0.871 respectively.

Conclusion: These results indicate that the mRNA expressions of CXCR1, CXCR2 and CXCL8 have high predictive value for PHC.