A COMPARISON OF THE EFFECTS OF HUMAN CHORIONIC GONADOTROPIN AND OXYTOCIN ON OVULATION IN PCOS PATIENTS FROM 2015 UNTIL 2018

MOJGAN JAVEDANI MASROUR^1*, ZAHRA AZAD²

¹Research and Clinical Center of Gynecology and Fertility, Shahid Akbarabadi Hospital, Iran University of Medical Sciences, Tehran, Iran - ²Research and Clinical Center of Gynecology and Fertility, Shahid Akbarabadi Hospital, Iran University of Medical Sciences, Tehran, Iran

Background and objective: Polycystic Ovary Syndrome [PCOS] is regarded as the most prevalent endocrine disorder and is often (but not always) featured by ovulatory dysfunction resulting in amenorrhea or oligo (Rotterdam 2003 consensus). The current study is carried out to compare the effects of oxytocin and chorionic gonadotropin (HCG) in inducting pregnancy and ovulation in women afflicted with the polycystic ovary syndrome.

Even though clomiphene is still regarded as the major treatment in patients afflicted with the polycystic ovary syndrome, the failure of ovulation in clomiphene-resistant women is considered as a significant and serious clinical topic.

Materials and methods: In a prospective research, 150 infertile clomiphene-resistant patients admitted to Akbarabadi hos- pital in Tehran from 2015 until 2018 were parted into three groups at random and received (100 mg clomiphene-citrate + 8 units of oxytocin), (100mg clomiphene-citrate + 10000 units of HCG) and (100mg clomiphene-citrate + 8 units of oxytocin and 10000 units of HCG). The treatment progress was determined by the number and size of follicles imaged using Transvaginal ultrasonog- raphy. To verify ovulation, the progesterone serum concentration was estimated. The rates of biochemical pregnancy and ovula- tion were compared in the mentioned three groups.

Results: 150 patients went through the study. There was no major difference among the groups regarding the ovulation rate or the number of follicles [p>0.05], neither was there any significant side effects observed in any groups.

Conclusion: Based on the findings of the current study, it can be concluded that because there is no difference in ovulation, OT can play a role in human ovulation either separately or coactively with other ovulatory mechanisms, and that the secretion of OT may be controlled by progesterone and ovarian estradiol. Moreover, the findings suggest that in clomiphene-resistance patients, OT might perform some role in regulating luteolysis.