CORRELATION BETWEEN SURVIVIN OVEREXPRESSION AND CLINICO-PATHOLOGICAL FEATURES OF INVASIVE CERVICAL CANCER: A META-ANALYSIS

HUI-RONG LI¹, JI-LI BAI², RUI XU2, YAN KONG¹

¹Department of Obstetrics and Gynecology, Shandong Provincial Third Hospital, Jinan City, Shandong Province 250000, China - ²Department of Obstetrics and Gynecology, the Third People’s Hospital of Lixia District of Jinan City, Jinan city, Shandong Province 250100, China

Objective: To systematically evaluate the correlation between overexpression of survivin and clinicopathological features of invasive cervical cancer.

Methods: EMBASE, Medline, PubMed, Wan Fang, and VIP databases from 2001 were searched for published case-control studies on invasive clinical pathologies associated with cervical cancer as they relate to the overexpression of survivin. The data were screened and collected independently by two reviewers, and thereafter subjected to meta-analysis using RevMan5.2 analysis software version after assessing risk of bias.

Results: Meta-analysis of 21 included articles showed that the clinical pathology features of invasive cervical cancer were generally accompanied by survivin overexpression; the expression of survivin in lymph node metastasis tissue was higher than that in non-metastasis lymph tissue, and the depth of invasive infiltration was higher than that in superficial layer. Moreover, survivin expression was significantly higher in the cervical cancer group than in the CIN group, and also higher in clinical stage III than in clinical stage II. There was a positive correlation between survivin and the clinical features of symptoms [OR = 5.52, 95 % CI = 4.09, 7.46; p < 0.00001].

Conclusion: High expression of survivin is consistent with clinical pathology of invasive cervical cancer, and the intensity of expression is positively correlated with the degree of pathological features.