A CASE OF MULTIPLE AUTOIMMUNITY COMPLICATED BY SIADH

LUIGI RAMPELLO*, FRANCESCO PATTI*, LIBORIO RAMPELLO*, ANTONIO ARCIDIACONO**, MARIO ZAPPIA*

¹GF Ingrassia Department, Neurosciences Section, University of Catania, Via Santa Sofia 78, 95123, Catania, Italy - ²Biometec Department, University of Catania, Via Santa Sofia 78, 95123, Catania, Italy

Central nervous system (CNS) vasculitides are rare, often severe diseases, difficult to diagnose for the lack of specific symp- toms and with a poor outcome. We report a case of CNS vasculitis in a 57-year-old patient suffering from multiorgan dysimmune syn- drome characterised by celiac disease, ulcerative colitis and diabetes mellitus. Cognitive deterioration, gait impairment and balance loss were the main clinical findings, and the patient was able to walk in 3 years. Moreover, inappropriate secretion of adiuretin syn- drome occurred, making the patient’s treatment more complex. Methylprednisolone and monthly intravenous pulse of cyclophos- phamide boosters were administered; plasma-exchange, intravenous immunoglobulins and rituximab were sequentially used with no benefit.