STUDY ON PROTECTING EFFECTS OF PARTHENOLIDE ON HEPATIC INJURY IN RATS WITH SEVE- RE ACUTE PANCREATITIS

GAOZHONG LI^1,2, GUANGSHENG ZHAI³, HONG TAO⁴, JINGMEI CAO², XIULIAN WANG², ZHAOSHENG CHEN¹, MIN LI², KUNMING HUANG², JIANQIANG GUO¹

¹Department of Gastroenterology, the second hospital of Shandong University, No. 247 of Beiyuan Street, Jinan 250033, Shandong Province, China - ²Department of Gastroenterology, Zibo Central Hospital, No. 54 West of Gongqingtuan Road, Zhangdian District, Zibo 255036, Shandong Province, China - ³Department of Radiotheraphy, Zibo Central Hospital, No. 54 West of Gongqingtuan Road, Zhangdian District, Zibo 255036, Shandong Province, China - ⁴Division of Clinical Skill Training Center, Zibo Central Hospital, No. 54 West of Gongqingtuan Road, Zhangdian District, Zibo 255036, Shandong, China

Objective: Our study was designed to investigate the protective effects of parthenolide on hepatic injury in rats with severe acute pancreatitis (SAP).

Methods: The SAP rat models were prepared and randomly devided into five groups，the model control group, parthenolide treated group with different doses of parthenolide, and the sham operated group. The levels of AMY, ALT, AST, IL-6 and TNF-α in serum, NF-κB expression and hepatic pathological changes in all groups were detected.

Results: The levels of AMY, ALT, AST, IL-6 and TNF-α in serum and expression levels of NF-κB were lower in parthenolide treated groups than that in model control group. The model control group showed obviously pathological changes compared with sham group, while the administration of parthenolide dose-dependently inhibited the changes.

Conclusion: Parthenolide demonstrated a well curative capability on rats with SAP.