RELATIONSHIP BETWEEN TRIMETHYLAMINE N-OXIDE AND TOTAL CARDIOVASCULAR RISK IN THE POPULATION OF CENTRAL KAZAKHSTAN

MARCHENKO ALEXANDR BORISOVICH¹, IVASENKO SVETLANA ALEKSANDROVNA¹, LARYUSHINA YELENA MIKHAILOVNA¹, TURGUNOVA LYUDMILA GENNADIEVNA¹, TURMUKHAMBETOVA ANAR AKYLBEKOVNA¹, DAN MORARU³, ANTONELLA CHESCA^2.3

¹Karaganda State Medical University, Karaganda, Kazakhstan - ²Transilvania University of Brașov, Romania - ³Clinical Hospital of Pneumophtysiology Brasov, Romania

Aim: To investigate relationship between the level of trimethylamine N-oxide (TMAO) and total cardiovascular risk (CVR) among the population of Central Kazakhstan.

Materials and methods: The cross-sectional investigation of urban and rural population of the Karaganda region was carried out. A total of 1,235 residents of the Karaganda region aged 18 to 65 were examined. In addition to calculating the total cardiova- scular risk on the Systemic Coronary Risk Evalution (SCORE) scale, questionnaires, general laboratory tests, the level of TMAO was determined by the high performance liquid chromatography with mass-selective mass spectrometry (HPLC-MS/MS).

Results: There was a strong direct relationship between the level of TMAO and the total CVR in men (r = 0.907, p <0.001), a moderate direct relationship in women (r = 0.559, p <0.001). According to the results of the binary logistic regression, the OR for men is 4.348 (95% CI 1.684;11.227, p <0.005), the OR for women is 1.624 (95% CI 1.408;1.837, <0.001).

Conclusion: Thus, the relationship between elevated titers of TMAO and high total cardiovascular risk showed common pathogenetic mechanisms in its development and confirmed the diagnostic and prognostic significance of these indicators among the population of the Central Kazakhstan.