LONG-TERM OUTCOME OF THE ENTERPRISE STENT IN THE TREATMENT OF WIDE-NECKED CEREBRAL ANEURYSMS

BU-LANG GAO^*, XUE-JING ZHANG, QIONG-YING FAN, WEI-LI HAO, CONG-HUI LI, SONG-TAO YANG

Departments of Medical Research and Neurosurgery, Shijiazhuang First Hospital, Shijiazhuang, Hebei 050011, China

Introduction: The long-term results of intracranial aneurysms treated with the Enterprise stent is not known. This study was to investigate the safety and long-term outcome of the Enterprise stent in the treatment of wide-necked intracranial aneurysms.

Materials and methods: Sixty-eight patients harboring 78 intracranial aneurysms were treated with the Enterprise stent-assi- sted embolization with or without coiling. Angiographic data and clinical outcomes before and after stenting and at follow-up were retrospectively evaluated.

Results: Seventy-seven Enterprise stents were successfully deployed in the desired position (100%). Seven procedure-related complications (10.3%) occurred including thrombosis formation in two patients, coil protrusion in two and stent dislocation in three. Twelve aneurysms were treated with stent deployment alone. Sixty-six aneurysms were treated with stent-assisted coiling, resulting in complete occlusion in 46 aneurysms (69.7%), near complete in 15 (22.7%) and incomplete in 5 (7.6%). At follow-up of 12-55 months (mean 38), progressive thrombosis occurred in 23 (71.9%) aneurysms, and aneurysm regrowth in 11 cases (18.0%). Stenting signifi- cantly (P<0.05) increased the parent artery diameters to 3.72±0.09 mm at point B and 3.43±0.1mm at D. At the last angiographic follow-up, the artery diameter was significantly (P<0.05) decreased to 3.45±0.2 mm at point B and 3.03±0.14 mm at D, with a medium asymptomatic in-stent stenosis in six patients (8.8%).

Conclusion: The Enterprise stent reconstruction of the parent artery for treating intracranial aneurysms is safe and effective with long-term asymptomatic instent stenosis.